Cytomegalovirus-induced immunopathology and its clinical consequences

Clinical Immunology and Immunopathology

INTRODUCTION ENL (4–6). However, there was no explanation for the mode of action of thalidomide in lepra reactions. In the early 1980s, with the increasing understandSince the synthesis of thalidomide (a-N-phthalimiing of the roles of particular cells in the developing doglutarimide) by Kunz and others in 1956 (1) for use immune response, it became clear that some diseases as a sedative, no dru...

Clinical Immunology and Immunopathology

*College of Medicine and College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois 60612; †Center for Comparative Medicine, Baylor College of Medicine, Houston, Texas 77030-3498; ‡Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814-4799; §University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania 15213; and University o...

Clinical Immunology and Immunopathology

Clinical Immunology and Immunopathology

cytokines, and then the phenomenon is resurrected unThis paper presents some questions and issues reder a different name. garding the concept of the Th1/Th2 dichotomy and Parenthetically, the phenomenon of the ‘‘T suppressummarizes results using an hsp60 peptide to treat the sor cell’’ has been unusually resistant to its molecular spontaneous autoimmune process of diabetes in NOD resurrection. ...

Clinical Immunology and Immunopathology

There is an increasing incidence of sepsis among hospitalized patients. Also, high mortality associated with sepsis and septic shock persists despite appropriate antibiotic therapy. Recent investigations have demonstrated that bacterial antigens stimulate a cascade of cellular mediators or cytokine release. In sepsis and septic shock the response of these cytokines often exceeds natural downreg...